Inferring pleiotropy by network analysis: linked diseases in the human PPI network

analysis of power in the network society

اندیشمندان و صاحب نظران علوم اجتماعی بر این باورند که مرحله تازه ای در تاریخ جوامع بشری اغاز شده است. ویژگیهای این جامعه نو را می توان پدیده هایی از جمله اقتصاد اطلاعاتی جهانی ، هندسه متغیر شبکه ای، فرهنگ مجاز واقعی ، توسعه حیرت انگیز فناوری های دیجیتال، خدمات پیوسته و نیز فشردگی زمان و مکان برشمرد. از سوی دیگر قدرت به عنوان موضوع اصلی علم سیاست جایگاه مهمی در روابط انسانی دارد، قدرت و بازتولید...

Inferring Gene Function and Network Organization in Drosophila Signaling by Combined Analysis of Pleiotropy and Epistasis

High-throughput genetic interaction screens have enabled functional genomics on a network scale. Groups of cofunctional genes commonly exhibit similar interaction patterns across a large network, leading to novel functional inferences for a minority of previously uncharacterized genes within a group. However, such analyses are often unsuited to cases with a few relevant gene variants or sparse ...

Network Analysis in sociality

Core and peripheral connectivity based cluster analysis over PPI network

A number of methods have been proposed in the literature of protein-protein interaction (PPI) network analysis for detection of clusters in the network. Clusters are identified by these methods using various graph theoretic criteria. Most of these methods have been found time consuming due to involvement of preprocessing and post processing tasks. In addition, they do not achieve high precision...

Inferring the human microRNA functional similarity and functional network based on microRNA-associated diseases

MOTIVATION It is popular to explore meaningful molecular targets and infer new functions of genes through gene functional similarity measuring and gene functional network construction. However, little work is available in this field for microRNA (miRNA) genes due to limited miRNA functional annotations. With the rapid accumulation of miRNAs, it is increasingly needed to uncover their functional...